IGF-I IS INFALLIBLE NOT FOR DIAGNOSIS OF GH DEFICIENCY, IN CHILD, INFANT AND YOUTH: CAIO JR, J. S. ET CAIO DRA.
CHILDREN AND CHILD, YOUTH, ADOLESCENCE WITH PRESENTS THE CONSTITUTIONAL LAG ADOLESCENT LOW VALUES OF IGF-1 PURSUANT TO CHRONOLOGICAL AGE, BUT NORMAL VALUES FOR BONE AGE AND MAY ALSO SUBMIT A DECREASE OF RESPONSE TO GH SECRETAGOGUES. PHYSIOLOGY-ENDOCRINOLOGY-NEUROENDOCRINOLOGY-ENDOCRINE- PEDIATRICS (SUBDIVISION OF ENDOCRINOLOGY); DR. JOÃO SANTOS CAIO JR. ET DRA. HENRIQUETA VERLANGIERI CAIO.
They should be interpreted taking into account nutrition, psychosocial status and bone age.
The IGFBP-3 is GH- dependent, and their concentrations, also if they are low, consist of evidence of growth hormone deficiency (GHD)in comparison with the separate determination of IGF-1. The Growth Hormone Resarch Society established criteria that attempt to regulate the diagnosis of growth hormone deficiency (GHD) phase child, childhood, youth or adolescence despite the variability of methods. These criteria use the findings of several clinical conditions associated with growth hormone deficiency (GHD), the severity of the longitudinal or linear low height and the degree and duration of the reduction in growth velocity in order to identify individuals who may possess growth hormone deficiency (GHD). Despite marked structural similarities between growth hormone from different species, only human growth hormones and primates have significant effects in humans. GH secretion several molecular forms of GH loop. Much of growth hormone in the circulation is bound to a protein (binding protein growth hormone, GHBP) which is derived from the growth hormone receptor. GH is secreted into the blood by the somatotroph cells of the anterior pituitary gland in larger amounts than any other pituitary hormone. Secretion levels are higher during puberty. The transcription factor PIT- 1 stimulates both the development of these cells and their production of GH. The failure of development of these cells, and the destruction of the anterior pituitary gland, resulting in GHD. Regulatory peptides released by neurosecretory nuclei of hypothalamus into the portal venous blood surrounding the pituitary are the main drivers of GH secretion by somatotropes. However, although the balance of these stimulating and inhibiting peptides determines GH release, this balance is affected by many physiological stimulators and inhibitors of GH secretion.
Stimulators of GH secretion include: growth hormone releasing hormone (GHRH) from the arcuate nucleus * ghrelin * Sleep * Exercise * low blood sugar (hypoglycemia) * dietary protein arginine * Estradiol *. Inhibitors of GH secretion include: somatostatin inhibits the periventricular nucleus * circulating concentrations of GH and IGF-I (negative feedback) * dietary carbohydrates * glucocorticoids. Beyond control by endogenous processes, a number of foreign compounds (xenobiotics) is now known to influence GH secretion and function, highlighting the fact that the GH-IGF axis is an emerging target for certain endocrine disrupters. The diagnostic guidelines and considerations statement Growth Hormone Research Society if longitudinal or linear low height test with a therapeutic with growth hormone GH by recombinant DNA 3 to 6 months to determine the growth response may be required; if growth increases more than 2 cm/year, likely the child will benefit from treatment with GH-growth hormone, no matter what the tests show originally.
Dr. João Santos Caio Jr.
Endocrinologia – Neuroendocrinologista
CRM 20611
Dra. Henriqueta V. Caio
Endocrinologista – Medicina Interna
CRM 28930
1. Crianças nascidas pequenas para a idade gestacional (PIG) não têm apenas risco de baixa estatura, mas também poderá ter problemas com o desenvolvimento neurológico e dificuldades comportamentais...
http://hormoniocrescimentoadultos.blogspot.com
2. A terapia estabelecida com altas doses de hormônio de crescimento (GH), tem se mostrado eficaz, não só para a normalização da baixa estatura em criança, infantil, juvenil e adolescente, mas também para o aumento da circunferência da cabeça em crianças PIG...
http://longevidadefutura.blogspot.com
3. Dada a associação com baixo peso ao nascer, a circunferência da cabeça era subnormal, pontuações mais baixas sobre as medidas em idade escolar de capacidade cognitiva e maior classificação indicativa de problemas de atenção e hiperatividade...
http://imcobesidade.blogspot.com
AUTORIZADO O USO DOS DIREITOS AUTORAIS COM CITAÇÃO
DOS AUTORES PROSPECTIVOS ET REFERÊNCIA BIBLIOGRÁFICA.
Referências Bibliográficas:
Caio Jr, João Santos, Dr.; Endocrinologista, Neuroendocrinologista, Caio,H. V., Dra. Endocrinologista, Medicina Interna – Van Der Häägen Brazil, São Paulo, Brasil; "Growth Hormone Deficiency". UK Child Growth Foundation. Retrieved 2009-01-16; "Growth failure (in children) - human growth hormone (HGH)" (pdf). National Institute for Clinical Excellence. 2008-09-25. Retrieved 2009-01-16; James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0; "The Use of Growth Hormone Replacement in Adult Patients with Severe Growth Hormone Deficiency" (pdf). The Society for Endocrinology. 2000-10-01. Retrieved 2009-01-1; 8 "Human Growth Hormone Deficiency". HGH. Retrieved 20 January 2012; "Human growth hormone (somatropin) in adults with growth hormone deficiency". National Institute for Clinical Excellence. 2006-07-01. Retrieved 2009-01-16; Rappold GA, Fukami M, Niesler B, et al. (March 2002). "Deletions of the homeobox gene SHOX (short stature homeobox) are an important cause of growth failure in children with short stature". J. Clin. Endocrinol. Metab. 87 (3): 1402–6. doi:10.1210/ jc.87.3.1402. PMID 11889216; Saborio P, Hahn S, Hisano S, Latta K, Scheinman JI, Chan JC (October 1998). "Chronic renal failure: an overview from a pediatric perspective". Nephron 80 (2): 134–48.doi:10.1159/ 000045157. PMID 9736810; Molitch ME, Clemmons DR, Malozowski S, et al. (May 2006). "Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society Clinical Practice Guideline". J. Clin. Endocrinol. Metab. 91 (5): 1621–34. doi:10.1210/ jc.2005-2227. PMID 16636129; Aimaretti G, Corneli G, Razzore P, et al. (May 1998). "Comparison between insulin-induced hypoglycemia and growth hormone (GH)-releasing hormone + arginine as provocative tests for the diagnosis of GH deficiency in adults". J. Clin. Endocrinol. Metab. 83 (5): 1615 8. doi:10.1210/jc.83.5.1615. PMID 9589665. Retrieved 2008-07-23; "Guidance on the use of human growth hormone (somatropin) in children with growth failure" (pdf). National Institute for Clinical Excellence. 2002-05-01. Retrieved 2009-01-16; "Consensus Guidelines for Adult Growth Hormone Deficiency 2007".
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